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In animal modls, atovastatin lows plasma cholstol and lipopotin lvls by inhibiting HMG-CoA ductas and cholstol synthsis in th liv and by incasing th numb hpatic LDL cptos on th cll suac tnhanc uptak and catabolism LDL; atovastatin alsducs LDL poduction and th numb LDL paticls.
Myopathy should b considd in any patint with dius myalgias, muscl tndnss waknss, and/makd lvation CPK. Patints should b advisd tpot pomptly unxplaind muscl pain, tndnss, waknss, paticulaly i accompanid by malais v i muscl signs and symptoms psist at discontinuing ATOLIP CV . ATOLIP CV thapy should b discontinud i makdly lvatd CPK lvls occu myopathy is diagnosd suspctd.
Duc th isk non-atal MI duc th isk atal and non-atal stok duc th isk vasculaization pocdus duc th isk hospitalization CH duc th isk angina.
Ztimib: Th us ztimib alon is associatd with muscl-latd vnts, including habdomyolysis. Th isk ths vnts may, tho, b incasd with concomitant us ztimib and ATOLIP CV . Appopiat clinical monitoing ths patints is commndd.
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atorlip is not allowed to people who have liver problems or unexplained abnormal liver function tests.